Title:Graph-theoretical approaches to 3D genome organization
Date: March 29, 2019 (Friday)
Time: 4:00 pm - 5:00 pm
Venue: Room 121, 1/F, Ho Sin-Hang Engineering Building, The Chinese University of Hong Kong, Shatin, N.T.
Speaker: Dr. Koon-Kiu Yan
Research Scientist
St Jude Children’s Research Hospital


The packing of a linear eukaryotic genome within a cell nucleus is dense and highly organized. Recently, proximity-ligation-based assays such as Hi-C have provided insights into such a complex structure. Understanding the role of 3D genome in gene regulation is thus a major area of research. By capturing the interactions between genomic elements, graph-based approaches present a simple but powerful toolbox to understand the 3D genome. In this talk, I will highlight a few projects that utilize graph-theoretical methods to decipher the 3D genome from Hi-C data, including the quantification of reproducibility in Hi-C data, the detection of the so-called topologically associating domains (TADs), and the interplay between spatial proximity and gene expression.


 Koon-Kiu Yan got his B.Sc. in math/physics and his M.Phil. in physics from the University of Hong Kong. He earned his Ph.D. degree in Physics from Stony Brook University; his dissertation was on the statistical mechanics of complex networks. He received his postdoc training at Yale University. Since then has been working on developing methods for deciphering the organizational principles of biological systems. He is currently a research scientist in St Jude Children’s Research Hospital.

Enquiries: Mr. Cyrus Lee at tel. 3943 8440

For more information, please refer to http://www.cse.cuhk.edu.hk/en/events