The Chinese University of Hong Kong
Department of Computer Science and Engineering


Title: Design and Test of Micro-Electrode-Dot-Array Digital Microfluidic Biochips
Date: April 28, 2017 (Friday)
Time: 2:00 p.m. - 3:00 p.m.
Venue: Room 1009, William M. W. Mong Engineering Building (ERB 1009),
The Chinese University of Hong Kong,
Shatin, N.T.
Speaker: Prof. Tsung-Yi HO
Department of Computer Science
National Tsing Hua University, Taiwan



A digital microfluidic biochip (DMFB) is an attractive technology platform for automating laboratory procedures in biochemistry. However, today's DMFBs suffer from several limitations: (i) constraints on droplet size and the inability to vary droplet volume in a fine-grained manner; (ii) the lack of integrated sensors for real-time detection; (iii) the need for special fabrication processes and reliability/yield concerns. To overcome the above problems, DMFBs based on a micro-electrode-dot-array (MEDA) architecture, and fabricated using a TSMC 350 nm process, have recently been demonstrated.

This presentation will first describe a biochemistry synthesis approach for such MEDA biochips. This synthesis method targets operation scheduling, module placement, routing of droplets of various sizes, and diagonal movement of droplets in a two-dimensional array. Simulation results using benchmarks and experimental results using a fabricated MEDA biochip will be presented to demonstrate the effectiveness of the proposed co-optimization technique. Finally, the presentation will describe an efficient built-in self-test (BIST) solution for MEDA biochips. Simulation results based on HSPICE and experiments using fabricated MEDA biochips will highlight the effectiveness of the proposed BIST architecture.



Tsung-Yi Ho received his Ph.D. in Electrical Engineering from National Taiwan University in 2005. He is a Professor with the Department of Computer Science of National Tsing Hua University, Hsinchu, Taiwan. His research interests include design automation and test for microfluidic biochips and nanometer integrated circuits. He has presented 10 tutorials and contributed 11 special sessions in ACM/IEEE conferences, all in design automation for microfluidic biochips. He has been the recipient of the Invitational Fellowship of the Japan Society for the Promotion of Science (JSPS), the Humboldt Research Fellowship by the Alexander von Humboldt Foundation, and the Hans Fischer Fellow by the Institute of Advanced Study of the Technical University of Munich. He was a recipient of the Best Paper Awards at the VLSI Test Symposium (VTS) in 2013 and IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems in 2015. He served as a Distinguished Visitor of the IEEE Computer Society for 2013-2015, the Chair of the IEEE Computer Society Tainan Chapter for 2013-2015, and the Chair of the ACM SIGDA Taiwan Chapter for 2014-2015. Currently he serves as an ACM Distinguished Speaker, a Distinguished Lecturer of the IEEE Circuits and Systems Society, and Associate Editor of the ACM Journal on Emerging Technologies in Computing Systems, ACM Transactions on Design Automation of Electronic Systems, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems, and IEEE Transactions on Very Large Scale Integration Systems, Guest Editor of IEEE Design & Test of Computers, and the Technical Program Committees of major conferences, including DAC, ICCAD, DATE, ASP-DAC, ISPD, ICCD, etc.


Enquiries: Ms Ricola Lo at tel 3943 8439

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